WITHDRAWN: Combinations of cyclodextrins and polyamidoamine dendrimer as a novel refolding system for protein
نویسندگان
چکیده
منابع مشابه
Polyamidoamine Dendrimer Conjugates with Cyclodextrins as Novel Carriers for DNA, shRNA and siRNA
Gene, short hairpin RNA (shRNA) and small interfering RNA (siRNA) delivery can be particularly used for the treatment of diseases by the entry of genetic materials mammalian cells either to express new proteins or to suppress the expression of proteins, respectively. Polyamidoamine (PAMAM) StarburstTM dendrimers are used as non-viral vectors (carriers) for gene, shRNA and siRNA delivery. Recent...
متن کاملPotential Use of Polyamidoamine Dendrimer Conjugates with Cyclodextrins as Novel Carriers for siRNA
Cyclodextrin (CyD)-based nanoparticles and polyamidoamine (PAMAM) starburst dendrimers (dendrimers) are used as novel carriers for DNA and RNA. Recently, small interfering RNA (siRNA) complex with β-CyD-containing polycations (CDP) having adamantine-PEG or adamantine-PEG-transferrin underwent a phase I study for treatment of solid tumors. Multifunctional dendrimers can be used for a wide range ...
متن کاملPolypseudorotaxanes of pegylated α-cyclodextrin/polyamidoamine dendrimer conjugate with cyclodextrins as a sustained release system for DNA.
Nonviral gene delivery suffers from a number of limitations including short transgene expression times and low transfection efficiency. In this study, we examined whether polypseudorotaxanes (PPRXs) of polyethylene glycol (PEG, molecular weight: 2,000)-grafted α-cyclodextrin (α-CyD)/polyamidoamine dendrimer conjugate (PEG-α-CDE) with CyDs have the potential for the novel sustained release syste...
متن کاملPotential use of polypseudorotaxanes of pegylated polyamidoamine dendrimer with cyclodextrins as novel sustained release systems for DNA.
In this study, we demonstrated the potential use of polypseudorotaxanes (PPRXs) of polyethylene glycol (PEG, molecular weight: 2000)-grafted polyamidoamine dendrimer (PEG-dendrimer) with cyclodextrins (CyDs) as novel sustained release systems for plasmid DNA (pDNA). PEG-dendrimer/pDNA complex formed PPRXs with α-CyD and γ-CyD solutions, but not with β-CyD solution. In the PEG-dendrimer/CyDs PPR...
متن کاملUsing Generation 3 Polyamidoamine Dendrimer as Adsorbent for the Removal of Pentavalent Arsenic from Aqueous Solutions
Introduction: Arsenic is known as a carcinogenic compound in drinking water. It can cause acute and chronic effects on human health. In this study, the effect of polyamidoamine dendrimer generation 3 (PAMAM G3) as adsorbents for removal of arsenic (V) from aqueous solutions was evaluated. Materials and Methods: Adsorption experiment was studied in batch system and the effect of different varia...
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ژورنال
عنوان ژورنال: Asian Journal of Pharmaceutical Sciences
سال: 2015
ISSN: 1818-0876
DOI: 10.1016/j.ajps.2015.11.076